Article

Unravelling the effects of disease-associated mutations in TDP-43 protein via molecular dynamics simulation and machine learning

2021-07-28

Abstract excerpt

Over the last two decades, the pathogenic aggregation of TAR DNA-binding protein 43 (TDP-43) is found to be strongly associated with several fatal neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTD), etc. While the mutations and truncation in TDP-43 protein have been suggested to be responsible for TDP-43 pathogenesis by accelerating the aggregation pr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5d024fd8-8e2a-502a-b20e-70e28e4a81db
DOI: 10.1101/2021.07.28.454112

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Unravelling the effects of disease-associated mutations in TDP-43 protein via molecular dynamics simulation and machine learningDOI 10.1101/2021.07.28.454112Read

Novel insights into the structural changes induced by disease-associated mutations in TDP-43: a computational approach.Semantic proximity Read

The proteinopathy of D169G and K263E mutants at the RNA Recognition Motif (RRM) domain of tar DNA-binding protein (tdp43) causing neurological disorders: A computational study.Semantic proximity Read

Structural analysis of disease-related TDP-43 D169G mutation: linking enhanced stability and caspase cleavage efficiency to protein accumulation.Semantic proximity Read

Atomistic Insights into A315E Mutation-Enhanced Pathogenicity of TDP-43 Core Fibrils.Semantic proximity Read

Unraveling the toxic effects mediated by the neurodegenerative disease-associated S375G mutation of TDP-43 and its S375E phosphomimetic variant.Semantic proximity Read

Decoding TDP-43: the molecular chameleon of neurodegenerative diseasesSemantic proximity Read

Influence of ALS-linked M337V mutation on the conformational ensembles of TDP-43321-340 peptide monomer and dimer.Semantic proximity Read

Structural Insights Into TDP-43 and Effects of Post-translational ModificationsSemantic proximity Read

Aliphatic residues contribute significantly to the phase separation of TDP-43 C-terminal domainSemantic proximity Read

Dissecting the effect of ALS mutation S375G on the conformational properties and aggregation dynamics of TDP-43370-375 fragment.Semantic proximity Read

The Effect of Single and Double Acetylation of Lysine Residues on Structural and Dynamical Features of Human Splicing Factor TDP-43 - A Statistical Ensemble Analysis.Semantic proximity Read

Pathological C-terminal phosphomimetic substitutions alter the mechanism of liquid-liquid phase separation of TDP-43 low complexity domainSemantic proximity Read