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Parental History of Type 2 Diabetes Mellitus and PNPLA3 Polymorphism Increase the Risk of Severe Stages of Nonalcoholic Fatty Liver Disease.

Digestive diseases and sciences - 1 Feb 2024

Wajsbrot Natalia Balassiano, Leite Nathalie Carvalho, Franca Paulo Henrique Condeixa, Cardoso Claudia Regina Lopes, Salles Gil Fernando, Villela-Nogueira Cristiane A

Abstract excerpt

BACKGROUND & AIMS: In non-alcoholic fatty liver disease (NAFLD), the influence of parental history of type 2 diabetes (T2D) allied to single nucleotide polymorphisms (SNPs) in the offspring is not known. We aimed to investigate the impact of the parental history of T2D, PNPLA3 and TM6SF2 polymorphisms in liver steatosis and fibrosis. METHODS: This was a case-control study involving the offspring of T2D patients...

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PMID: 38112841
DOI: 10.1007/s10620-023-08214-7

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