Article
JAK2, CALR, and MPL Mutation Profiles in Colombian patients with BCR-ABL Negative Myeloproliferative Neoplasms.
Colombia medica (Cali, Colombia) - 1 Jan 2000
Giraldo-Rincón Ana Isabel, Naranjo Molina Sara, Gomez-Lopera Natalia, Aguirre Acevedo Daniel, Ucroz Benavidez Andrea, Gálvez Cárdenas Kenny, Cuellar Ambrosí Francisco, Torres Jose Domingo, Ospina Sigifredo, Palacio Katherine, Gaviria Jaramillo Lina, Muñeton Carlos Mario, Vasquez Palacio Gonzalo
Abstract excerpt
Background: Among the chronic myeloproliferative neoplasms (MPNs) not associated with BCR-ABL mutations are polycythemia vera, primary myelofibrosis, and essential thrombocythemia. These diseases are caused by mutations in genes, such as the JAK2, MPL, and CALR genes, which participate in regulating the JAK-STAT signaling pathway. Objective: This study aimed to establish the frequencies of mutations in the JAK2,...
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