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Clinical and Laboratory Features of JAK2 V617F, CALR, and MPL Mutations in Malaysian Patients with Classical Myeloproliferative Neoplasm (MPN).

International journal of environmental research and public health - 16 Jul 2021

Zulkeflee Razan Hayati, Zulkafli Zefarina, Johan Muhammad Farid, Husin Azlan, Islam Md Asiful, Hassan Rosline

Abstract excerpt

Mutations of JAK2V617F, CALR, and MPL genes confirm the diagnosis of myeloproliferative neoplasm (MPN). This study aims to determine the genetic profile of JAK2V617F, CALR exon 9 Type 1 (52 bp deletion) and Type 2 (5 bp insertion), and MPL W515 L/K genes among Malaysian patients and correlate these mutations with clinical and hematologic parameters in MPN. Mutations of JAK2V617F, CALR, and MPL were analyzed in...

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PMID: 34300032
DOI: 10.3390/ijerph18147582
PMCID: PMC8307561

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