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Article

Neuroticism increased risk of gastroesophageal reflux disease: Evidence from bidirectional Mendelian randomization.

Medicine - 18 Sept 2026

Yu Yan, Fu Zhifeng, Zhang Jingwen, Jiang Haixing

Abstract excerpt

Gastroesophageal reflux disease (GERD) is a common gastrointestinal disorder that severely reduces quality of life. Emerging data suggest that neuroticism, a personality trait associated with increased stress reactivity and sensitivity to physiological sensations, may contribute to GERD susceptibility. However, the causality remains unknown. A bidirectional Mendelian Randomization (MR) study was conducted to...

Read the complete abstract on PubMed

Topics

Humans
Gastroesophageal Reflux
Neuroticism
Mendelian Randomization Analysis
Genome-Wide Association Study
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

United Kingdom

Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 42760700
DOI: 10.1097/MD.0000000000050732
PMCID: PMC13593013

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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