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Article

Cognitive phenotypes: Unraveling the heterogeneity in cognitive dysfunction among patients with primary brain tumors receiving radiotherapy.

Neuro-oncology - 10 Feb 2025

Reyes Anny, Stasenko Alena, Hopper Austin, Kohli Jiwandeep S, Helm Jonathan L, Salans Mia, Prabhakaran Divya, Kamalyan Lily, Wilkinson Molly, Unnikrishnan Soumya, Karunamuni Roshan, Hattangadi-Gluth Jona, McDonald Carrie R

Abstract excerpt

BACKGROUND: Patients with primary brain tumors demonstrate heterogeneous patterns of cognitive dysfunction, which we explore using latent profile analysis to identify cognitive phenotypes and their trajectories in patients receiving radiotherapy (RT). METHODS: Ninety-six patients completed neuropsychological testing before and post-RT (3, 6, and 12 months) on a prospective longitudinal trial, including measures...

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PMID: 39248576
DOI: 10.1093/neuonc/noae183
PMCID: PMC11812028

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