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Generation of two induced pluripotent stem cell lines from hereditary amyloidosis patients with polyneuropathy carrying heterozygous transthyretin (TTR) mutation.

Stem cell research - 1 Feb 2024

Melesio Juan, Bonilauri Bernardo, Li Audrey, Pang Paul D, Liao Ronglih, Witteles Ronald M, Wu Joseph C, Sallam Karim

Abstract excerpt

Hereditary transthyretin amyloidosis with polyneuropathy (ATTR-PN) results from specific TTR gene mutations. In this study, we generated two induced pluripotent stem cell (iPSC) lines derived from ATTR-PN patients with heterozygous TTR gene mutations (Ala97Ser and Phe64Leu). These iPSC lines exhibited normal morphology, karyotype, high pluripotency marker expression, and differentiation into cells representing...

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Identifiers

PMID: 38100909
DOI: 10.1016/j.scr.2023.103265
PMCID: PMC10883469

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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