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Generation of two induced pluripotent stem cell lines from patients with cardiac amyloidosis carrying heterozygous transthyretin (TTR) mutation.

Stem cell research - 1 Oct 2023

Bonilauri Bernardo, Shin Hye Sook, Htet Min, Yan Christopher D, Witteles Ronald M, Sallam Karim, Wu Joseph C

Abstract excerpt

Specific mutations in the TTR gene are responsible for the development of variant (hereditary) ATTR amyloidosis. Here, we generated two human induced pluripotent stem cell (iPSC) lines from patients diagnosed with Transthyretin Cardiac Amyloidosis (ATTR-CM) carrying heterozygous mutation in the TTR gene (i.e., p.Val30Met). The patient-derived iPSC lines showed expression of high levels of pluripotency markers,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Coagulation, Bradykinin, Polyphosphates, and Angioedema

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Identifiers

PMID: 37788558
DOI: 10.1016/j.scr.2023.103215
PMCID: PMC10821799

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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