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Global genomic profiling of Klebsiella pneumoniae: A spatio-temporal population structure analysis

9 Dec 2023

Abstract excerpt

Klebsiella pneumoniae is an important clinical bacterial pathogen that has hypervirulent and multidrug-resistant variants. Uniform Manifold Approximation and Projection (UMAP) was used to cluster genomes of 16 797 K. pneumoniae strains collected, based on core genome distance, in over 100 countries during the period 1937 to 2021. A total of 60 high-density genetic clusters of strains representing the major...

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PMID: 38081547
DOI: 10.1016/j.ijantimicag.2023.107055

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