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Article

Lineage-specific evolution and resistance-virulence divergence in Klebsiella pneumoniae ST268: a global population genomic analysis.

Antimicrobial agents and chemotherapy - 1 Oct 2025

Dong Xu, Xiang Yanghui, Li Yi, Zhang Ying

Abstract excerpt

Klebsiella pneumoniae sequence type 268 (ST268) represents an emerging high-risk clone with significant clinical implications. Here, we present a comprehensive genomic analysis of 562 ST268 isolates collected from 44 countries across six continents between 2001 and 2024. Phylogenomic reconstruction revealed 10 distinct lineages with diverse geographic and functional signatures. Bayesian analysis dated the...

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Identifiers

PMID: 40952379
DOI: 10.1128/aac.00703-25
PMCID: PMC12486848

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