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Article

Airway environment drives the selection of quorum sensing mutants and promote Staphylococcus aureus chronic lifestyle

8 Dec 2023

Abstract excerpt

Staphylococcus aureus is a predominant cause of chronic lung infections. While the airway environment is rich in highly sialylated mucins, the interaction of S. aureus with sialic acid is poorly characterized. Using S. aureus USA300 as well as clinical isolates, we demonstrate that quorum-sensing dysfunction, a hallmark of S. aureus adaptation, correlates with a greater ability to consume free sialic acid,...

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Share to Antifungal resistance and susceptibility
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PMID: 38065959
DOI: 10.1038/s41467-023-43863-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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