Article
Antibodies against advanced glycation end-products and malondialdehyde-acetaldehyde adducts identify a new specific subgroup of hitherto patients with seronegative arthritis with a distinct clinical phenotype and an HLA class II association.
RMD open - 1 Dec 2023
van den Beukel Michelle D, van Wesemael Tineke J, Hoogslag Anna Titia W, Borggreven Nicole V, Huizinga Tom Wj, van der Helm-van Mil Annette Hm, Toes René Em, van der Woude Diane, Trouw Leendert A
Abstract excerpt
OBJECTIVE: In rheumatoid arthritis (RA) around two-thirds of patients are autoantibody positive for rheumatoid factor, anti-citrullinated protein antibodies and/or anti-carbamylated protein antibodies. The remaining seronegative subgroup of patients is clinically heterogeneous and thus far, biomarkers predicting the disease course are lacking. Therefore, we analysed the value of other autoantibodies in RA...
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