Article
Age-dependent genetic regulation of osteoarthritis: independent effects of immune system genes.
Arthritis research & therapy - 1 Dec 2023
Kenny Jacob, Mullin Benjamin H, Tomlinson William, Robertson Brett, Yuan Jinbo, Chen Weiwei, Zhao Jinmin, Pavlos Nathan J, Walsh John P, Wilson Scott G, Tickner Jennifer, Morahan Grant, Xu Jiake
Abstract excerpt
OBJECTIVES: Osteoarthritis (OA) is a joint disease with a heritable component. Genetic loci identified via genome-wide association studies (GWAS) account for an estimated 26.3% of the disease trait variance in humans. Currently, there is no method for predicting the onset or progression of OA. We describe the first use of the Collaborative Cross (CC), a powerful genetic resource, to investigate knee OA in mice,...
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