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Article

Development of an immunogenicity score for HLA-DQ eplets: A conceptual study.

HLA - 1 Jan 2021

Schawalder Lara, Hönger Gideon, Kleiser Marc, van Heck Michelle R, van de Pasch Loes A L, Vendelbosch Sanne, Rozemuller Erik H, Schaub Stefan

Abstract excerpt

Eplets are defined as distinct amino acid configurations on the surface of HLA molecules. The aim of this study was to estimate the immunogenicity of HLA-DQ eplets in a cohort of 221 pregnancies with HLA-DQ mismatches. We defined the immunogenicity of an eplet by the frequency of antibody responses against it. Around 90% of all listed DQB1 or DQA1 eplets were at least five times mismatched and thus included for...

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Identifiers

PMID: 33068062
DOI: 10.1111/tan.14110
PMCID: PMC7756751

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