Article
A transcriptomic and proteomic atlas of obesity and type 2 diabetes in cynomolgus monkeys
1 Aug 2023
Abstract excerpt
Obesity and type 2 diabetes (T2D) remain major global healthcare challenges, and developing therapeutics necessitates using nonhuman primate models. Here, we present a transcriptomic and proteomic atlas of all the major organs of cynomolgus monkeys with spontaneous obesity or T2D in comparison to healthy controls. Molecular changes occur predominantly in the adipose tissues of individuals with obesity, while...