Article
Sex-associated differences in frequencies and prognostic impact of recurrent genetic alterations in adult acute myeloid leukemia (Alliance, AMLCG).
Leukemia - 1 Jan 2024
Ozga Michael, Nicolet Deedra, Mrózek Krzysztof, Yilmaz Ayse S, Kohlschmidt Jessica, Larkin Karilyn T, Blachly James S, Oakes Christopher C, Buss Jill, Walker Christopher J, Orwick Shelley, Jurinovic Vindi, Rothenberg-Thurley Maja, Dufour Annika, Schneider Stephanie, Sauerland Maria Cristina, Görlich Dennis, Krug Utz, Berdel Wolfgang E, Woermann Bernhard J, Hiddemann Wolfgang, Braess Jan, Subklewe Marion, Spiekermann Karsten, Carroll Andrew J, Blum William G, Powell Bayard L, Kolitz Jonathan E, Moore Joseph O, Mayer Robert J, Larson Richard A, Uy Geoffrey L, Stock Wendy, Metzeler Klaus H, Grimes H Leighton, Byrd John C, Salomonis Nathan, Herold Tobias, Mims Alice S, Eisfeld Ann-Kathrin
Abstract excerpt
Clinical outcome of patients with acute myeloid leukemia (AML) is associated with demographic and genetic features. Although the associations of acquired genetic alterations with patients' sex have been recently analyzed, their impact on outcome of female and male patients has not yet been comprehensively assessed. We performed mutational profiling, cytogenetic and outcome analyses in 1726 adults with AML (749...
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