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LGR6 modulates intervertebral disc degeneration through regulation of macrophage efferocytosis

25 Apr 2025

Abstract excerpt

BACKGROUND AND OBJECTIVES: Intervertebral disc degeneration (IVDD) is a leading cause of chronic low back pain, characterized by extracellular matrix (ECM) degradation, excessive inflammation activation, and increased cell apoptosis. LGR6, a receptor known for its role in tissue regeneration, has recently been implicated in modulating macrophage efferocytosis, a process critical for clearing apoptotic cells and...

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PMID: 40281518
DOI: 10.1186/s12967-025-06427-0

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