Article
Comparative study of droplet-digital PCR and absolute Q digital PCR for ctDNA detection in early-stage breast cancer patients.
Clinica chimica acta; international journal of clinical chemistry - 1 Jan 2024
Sánchez-Martín Victoria, López-López Esperanza, Reguero-Paredes Diego, Godoy-Ortiz Ana, Domínguez-Recio Maria Emilia, Jiménez-Rodríguez Begoña, Alba-Bernal Alfonso, Elena Quirós-Ortega Maria, Roldán-Díaz María Dunia, Velasco-Suelto Jesús, Linares-Valencia Noelia, Garrido-Aranda Alicia, Lavado-Valenzuela Rocío, Álvarez Martina, Pascual Javier, Alba Emilio, Comino-Méndez Iñaki
Abstract excerpt
BACKGROUND: Analysis of circulating tumor DNA (ctDNA) is increasingly used for clinical decision-making in oncology. However, ctDNA could represent ≤ 0.1 % of cell-free DNA in early-stage tumors and its detection requires high-sensitive techniques such as digital PCR (dPCR). METHODS: In 46 samples from patients with early-stage breast cancer, we compared two leading dPCR assays for ctDNA analysis: QX200 droplet...
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