Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Controlling Trophoblast Cell Fusion in the Human Placenta—Transcriptional Regulation of Suppressyn, an Endogenous Inhibitor of Syncytin-1

7 Nov 2023

Abstract excerpt

Cell fusion in the placenta is tightly regulated. Suppressyn is a human placental endogenous retroviral protein that inhibits the profusogenic activities of another well-described endogenous retroviral protein, syncytin-1. In this study, we aimed to elucidate the mechanisms underlying suppressyn’s placenta-specific expression. We identified the promoter region and a novel enhancer region for the gene encoding...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Genetic Syndromes and Imprinting
Share to Pregnancy and preeclampsia studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38002309
DOI: 10.3390/biom13111627

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Controlling Trophoblast Cell Fusion in the Human Placenta—Transcriptional Regulation of Suppressyn, an Endogenous Inhibitor of Syncytin-1PMID 38002309Read ↗

Suppressyn localization and dynamic expression patterns in primary human tissues support a physiologic role in human placentationSemantic proximity Read ↗

A novel human endogenous retroviral protein inhibits cell-cell fusionSemantic proximity Read ↗

Epigenetic and non-epigenetic regulation of syncytin-1 expression in human placenta and cancer tissuesSemantic proximity Read ↗

Decreased Expression and Altered Methylation of Syncytin-1 Gene in Human Placentas Associated with PreeclampsiaSemantic proximity Read ↗

The role of syncytins in human reproduction and reproductive organ cancersSemantic proximity Read ↗

The Role of Syncytin in Placental Angiogenesis and Fetal GrowthSemantic proximity Read ↗

Implication of Human Endogenous Retrovirus Envelope Proteins in Placental FunctionsSemantic proximity Read ↗

Involvement of the HERV-derived cell-fusion inhibitor, suppressyn, in the fusion defects characteristic of the trisomy 21 placentaSemantic proximity Read ↗

TFEB controls syncytiotrophoblast differentiationSemantic proximity Read ↗

Genetic Diversity in the Suppressyn Gene Sequence: From Polymorphisms to Loss-of-Function Mutations.Semantic proximity Read ↗

Syncytin-1, syncytin-2 and suppressyn in human health and diseaseSemantic proximity Read ↗

Regulation of human trophoblast syncytialization by histone demethylase LSD1Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.