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Article

Deep topographic proteomics of a human brain tumour

24 Nov 2023

Abstract excerpt

The spatial organisation of cellular protein expression profiles within tissue determines cellular function and is key to understanding disease pathology. To define molecular phenotypes in the spatial context of tissue, there is a need for unbiased, quantitative technology capable of mapping proteomes within tissue structures. Here, we present a workflow for spatially-resolved, quantitative proteomics of tissue...

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PMID: 38001067
DOI: 10.1038/s41467-023-43520-8

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