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Genetic polymorphisms of CYP2B6 is a risk of metabolic associated fatty liver disease in Chinese population.

Toxicology and applied pharmacology - 15 Dec 2023

Zhang Jingwei, Ma Shijie, Zhou Wei, Feng Jing, Kang Yuwei, Yang Wei, Zhang Heping, Deng Fei

Abstract excerpt

BACKGROUND: The expression and activity of cytochrome P450 2B6 (CYP2B6) may be related to the metabolic associated fat liver disease (MAFLD). Since constitutive androstane receptor (CAR) is a classic transcriptional regulator of CYP2B6, and the single nucleotide polymorphisms (SNPs) of CYP2B6 and CAR are both associated with adverse reactions of efavirenz, we hypothesized that genetic polymorphisms of CAR might...

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PMID: 37995809
DOI: 10.1016/j.taap.2023.116770

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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