Article
NOTCH pathway mutation contributes to inferior prognosis in HBV-infected chronic lymphocytic leukemia.
Annals of hematology - 1 Mar 2024
Shang Chun-Yu, Bei Li-Ye, Wu Jia-Zhu, Sheng Hao-Rui, Yin Hua, Liang Jin-Hua, Wang Li, Li Jian-Yong, Li Yue, Xu Wei
Abstract excerpt
Chronic lymphocytic leukemia (CLL) patients with hepatitis B virus (HBV) infection have a poor prognosis, underlying mechanism remains unclear. NOTCH mutations are frequent in CLL and associated with disease progression and drug resistance. It is also reported to be associated with hepatitis infection in lymphoid malignancies. In order to investigate the relation between the NOTCH pathway and HBV-associated CLL,...
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