The NOTCH pathway is recurrently mutated in diffuse large B-cell lymphoma associated with hepatitis C virus infection.

doi:10.3324/haematol.2014.116855

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Article

The NOTCH pathway is recurrently mutated in diffuse large B-cell lymphoma associated with hepatitis C virus infection.

Haematologica - 1 Feb 2015

Arcaini Luca, Rossi Davide, Lucioni Marco, Nicola Marta, Bruscaggin Alessio, Fiaccadori Valeria, Riboni Roberta, Ramponi Antonio, Ferretti Virginia V, Cresta Stefania, Casaluci Gloria Margiotta, Bonfichi Maurizio, Gotti Manuel, Merli Michele, Maffi Aldo, Arra Mariarosa, Varettoni Marzia, Rattotti Sara, Morello Lucia, Guerrera Maria Luisa, Sciarra Roberta, Gaidano Gianluca, Cazzola Mario, Paulli Marco

Abstract excerpt

Hepatitis C virus has been found to be associated with B-cell non-Hodgkin lymphomas, mostly marginal zone lymphomas and diffuse large B-cell lymphoma. Deregulation of signaling pathways involved in normal marginal zone development (NOTCH pathway, NF-κB, and BCR signaling) has been demonstrated in splenic marginal zone lymphoma. We studied mutations of NOTCH pathway signaling in 46 patients with hepatitis C...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphoma, Large B-Cell, Diffuse

Share to Neoplasm Grading

Share to Neoplasm Recurrence, Local

Share to Receptor, Notch1

Share to Receptor, Notch2

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Identifiers

PMID: 25381127
DOI: 10.3324/haematol.2014.116855
PMCID: PMC4803124

Genes

NOTCH2
NOTCH1
BCR
SPEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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