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Article

LIPH contributes to glycolytic phenotype in pancreatic ductal adenocarcinoma by activating LPA/LPAR axis and maintaining ALDOA stability.

Journal of translational medicine - 21 Nov 2023

Han Lijie, Jiang Yongsheng, Shi Minmin, Gan Lina, Wu Zhichong, Xue Meilin, Zhu Youwei, Xiong Cheng, Wang Ting, Lin Xiaozhu, Shen Baiyong, Jiang Lingxi, Chen Hao

Abstract excerpt

BACKGROUND: LIPH, a membrane-associated phosphatidic acid-selective phospholipase A1a, can produce LPA (Lysophosphatidic acid) from PA (Phosphatidic acid) on the outer leaflet of the plasma membrane. It is well known that LIPH dysfunction contributes to lipid metabolism disorder. Previous study shows that LIPH was found to be a potential gene related to poor prognosis with pancreatic ductal adenocarcinoma (PDAC)....

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Share to Carcinoma, Pancreatic Ductal
Share to Fructose-Bisphosphate Aldolase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Neoplastic

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Identifiers

PMID: 37990271
DOI: 10.1186/s12967-023-04702-6
PMCID: PMC10664664

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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