Article
Altered HCAR3 expression may underlying the blunted niacin responses of the psychiatric disorders and the risk of schizophrenia.
Psychiatry and clinical neurosciences - 1 Feb 2024
Jiang Jie, Wang Dandan, Gao Yan, Sun Liya, Li Shuhui, Hu Xiaowen, Li Zhuyun, Zhang Juan, Ji Feng, Tian Yusheng, Guan Lili, Li Zhiqiang, He Lin, Wan Chunling
Abstract excerpt
AIM: Blunted niacin response (BNR) was an endophenotype of schizophrenia, but the underlying mechanism remains unclarified. The objective of this study was to verify whether genes associated with BNR pathway constitute the genetic basis and the pathological mechanism of BNR phenotypic psychiatric patients. METHODS: Two independent sample sets consisting of 971 subjects were enrolled in this study. A total of 62...
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