The impact of PLA2G4A and PTGS2 gene polymorphisms, and red blood cell PUFAs deficit on niacin skin flush response in schizophrenia patients.

doi:10.1016/j.plefa.2012.11.005

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The impact of PLA2G4A and PTGS2 gene polymorphisms, and red blood cell PUFAs deficit on niacin skin flush response in schizophrenia patients.

Prostaglandins, leukotrienes, and essential fatty acids - 1 Feb 2013

Nadalin Sergej, Giacometti Jasminka, Jonovska Suzana, Tomljanović Draško, Buretić-Tomljanović Alena

Abstract excerpt

We investigated the etiology of the attenuated niacin skin flush response in schizophrenia patients. Skin response to topical niacin of 0.1M, 0.01 M, 0.001 M, and 0.0001 M concentrations was rated using method of volumetric niacin response (VNR) and correlated to two functional A/G polymorphisms in genes: phospholipase A2 group IVA (BanI of the PLA2G4A), and rs689466 of the prostaglandin synthase-2 (PTGS2). We...

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PMID: 23219238
DOI: 10.1016/j.plefa.2012.11.005

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PTGS2

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