Polymorphisms in PLA2G6 and PLA2G4C genes for calcium-independent phospholipase A2 do not contribute to attenuated niacin skin flush response in schizophrenia patients.

doi:10.1016/j.plefa.2015.06.004

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Article

Polymorphisms in PLA2G6 and PLA2G4C genes for calcium-independent phospholipase A2 do not contribute to attenuated niacin skin flush response in schizophrenia patients.

Prostaglandins, leukotrienes, and essential fatty acids - 1 Sept 2015

Nadalin S, Radović I, Buretić-Tomljanović A

Abstract excerpt

We hypothesized that attenuated niacin skin flushing in schizophrenia patients might be associated with polymorphic variants in PLA2G6 and PLA2G4C genes (rs4375 and rs1549637 variations) which encode calcium-independent phospholipase A2 beta (iPLA2β) and cytosolic phospholipase A2 gamma (cPLA2γ) enzymes. The iPLA2β and cPLA2γ may play an important role in niacin-mediated signaling; in addition to their major role...

Topics

Adult
Croatia
Female
Flushing
Group IV Phospholipases A2
Group VI Phospholipases A2
Humans
Male
Middle Aged
Niacin
Polymorphism, Single Nucleotide
Schizophrenia

Source

Open in PubMed

Identifiers

PMID: 26160611
DOI: 10.1016/j.plefa.2015.06.004

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