Article
Endophenotype properties of niacin sensitivity as marker of impaired prostaglandin signalling in schizophrenia.
Prostaglandins, leukotrienes, and essential fatty acids - 1 Aug 2007
Smesny Stefan, Klemm Silke, Stockebrand Margit, Grunwald Sebastian, Gerhard Uwe-Jens, Rosburg Timm, Sauer Heinrich, Blanz Bernhard
Abstract excerpt
BACKGROUND: Disruption of arachidonic acid pathways and prostaglandin signalling has been implicated in the pathophysiology of schizophrenia. AIMS: We intended to study prostaglandin signalling in groups of young schizophrenia patients, first-degree relatives, and healthy controls in order to assess effects of heritability on this biological marker-one important endophenotype criterion. METHOD: Namely, we...
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