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Intracytoplasmic sperm injection induces transgenerational abnormalities in mice

15 Nov 2023

Abstract excerpt

In vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) are 2 major assisted reproductive techniques (ARTs) used widely to treat infertility. Recently, spermatogonial transplantation emerged as a new ART to restore fertility to young patients with cancer after cancer therapy. To examine the influence of germ cell manipulation on behavior of offspring, we produced F1 offspring by a combination of...

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PMID: 37966118
DOI: 10.1172/jci170140

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