Phenotypic assessment of male fertility status in transgenic animal models.

doi:10.1007/978-1-62703-038-0_45

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Article

Phenotypic assessment of male fertility status in transgenic animal models.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2013

de Kretser David M, O'Donnell Liza

Abstract excerpt

This chapter describes the approach to define the cause of male infertility in a genetically modified male mouse. It provides a guide to the establishment of the infertility status and whether it is due to the failure of mating or due to abnormalities of the sperm output, motility, and morphology. Further assessments define the nature of the spermatogenic defects and their severity and are designed to determine...

Topics

Animals
Fertility
Male
Mice
Mice, Transgenic
Microscopy
Microscopy, Electron
Phenotype
Sperm Count
Sperm Motility
Spermatogenesis
Spermatozoa
Testis

Source

Open in PubMed

Identifiers

PMID: 22992942
DOI: 10.1007/978-1-62703-038-0_45

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