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Whole gain of chromosome 19, not co-gain of chromosomes 19 and 20, characterizes a class of glioblastomas with more favorable outcomes

23 Oct 2023

Abstract excerpt

To the Editor: Glioblastoma, IDH-wildtype carries an abysmal prognosis but long-term survivors do exist (1). Co-gain of chromosomes 19 and 20 (+19/+20) has been reported as a favorable prognostic marker in glioblastoma (2), and several studies of long-term survivors have predicated portions of their analyses on this finding (3, 4). However, corroboration of the prognostic benefit of +19/+20 is limited (5, 6), and...

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PMID: 37964704
DOI: 10.1093/jnen/nlad092

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