Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impaired glycine neurotransmission causes adolescent idiopathic scoliosis

14 Nov 2023

Abstract excerpt

Adolescent idiopathic scoliosis (AIS) is the most common form of spinal deformity, affecting millions of adolescents worldwide, but it lacks a defined theory of etiopathogenesis. Because of this, treatment of AIS is limited to bracing and/or invasive surgery after onset. Preonset diagnosis or preventive treatment remains unavailable. Here, we performed a genetic analysis of a large multicenter AIS cohort and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Connective tissue disorders research
Share to Scoliosis diagnosis and treatment

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 37962965
DOI: 10.1172/jci168783

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impaired glycine neurotransmission causes adolescent idiopathic scoliosisPMID 37962965Read ↗

The importance of imperfect pre-clinical models in adolescent idiopathic scoliosis.Semantic proximity Read ↗

A missense variant in SLC39A8 is associated with severe idiopathic scoliosisSemantic proximity Read ↗

EPHA4 signaling dysregulation links abnormal locomotion and the development of idiopathic scoliosisSemantic proximity Read ↗

The astrocytic transporter SLC7A10 (Asc-1) mediates glycinergic inhibition of spinal cord motor neuronsSemantic proximity Read ↗

Identification of a Functional Susceptibility Variant for Adolescent Idiopathic Scoliosis that Upregulates Early Growth Response 1 (EGR1)-Mediated UNCX Expression.Semantic proximity Read ↗

Integrated Transcriptomic and Functional Analysis Reveals Tissue-Specific Molecular Pathology in Adolescent Idiopathic ScoliosisSemantic proximity Read ↗

Association between genetic polymorphisms and risk of adolescent idiopathic scoliosis in case-control studies: a systematic review.Semantic proximity Read ↗

Integrated transcriptomic and functional analysis reveals tissue-specific molecular pathology in adolescent idiopathic scoliosis.Semantic proximity Read ↗

The alanine-serine-cysteine-1 (Asc-1) transporter controls glycine levels in the brain and is required for glycinergic inhibitory transmission.Semantic proximity Read ↗

New Evidence Supporting the Role of FBN1 in the Development of Adolescent Idiopathic Scoliosis.Semantic proximity Read ↗

Adolescent Idiopathic Scoliosis: Fishy Tales of Crooked Spines.Semantic proximity Read ↗

Association of genetic variation in COL11A1 with adolescent idiopathic scoliosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.