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Sex-specific differences in DNA double-strand break repair of cycling human lymphocytes during aging

10 Sept 2021

Abstract excerpt

The gender gap in life expectancy and cancer incidence suggests differences in the aging process between the sexes. Genomic instability has been recognized as a key factor in aging, but little is known about sex-specific differences. Therefore, we analyzed DNA double-strand break (DSB) repair in cycling human peripheral blood lymphocytes (PBL) from male and female donors of different age. Reporter-based DSB...

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PMID: 34506302
DOI: 10.18632/aging.203519

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