Impacting T-cell fitness in multiple myeloma: potential roles for selinexor and XPO1 inhibitors

Abstract excerpt

Competent T-cells with sufficient levels of fitness combat cancer formation and progression. In multiple myeloma (MM), T-cell exhaustion is caused by several factors including tumor burden, constant immune activation due to chronic disease, age, nutritional status, and certain MM treatments such as alkylating agents and proteasome inhibitors. Many currently used therapies, including bispecific T-cell engagers,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to CAR-T cell therapy research
• Share to Multiple Myeloma Research and Treatments
• Share to Protein Degradation and Inhibitors