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Article

Travels with tau prions

11 Nov 2023

Abstract excerpt

Tau was originally identified as a microtubule associated protein, and subsequently recognized to constitute the fibrillar assemblies found in Alzheimer disease and related neurodegenerative tauopathies. Point mutations in the microtubule associated protein tau (MAPT) gene cause dominantly inherited tauopathies, and most predispose it to aggregate. This indicates tau aggregation underlies pathogenesis of...

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Identifiers

PMID: 37950616
DOI: 10.1002/cm.21806

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