Article
Airway and Blood Monocyte Transcriptomic Profiling Reveals an Antiviral Phenotype in Infants With Severe Respiratory Syncytial Virus Infection.
The Journal of infectious diseases - 1 Mar 2024
Chappin K, Besteman S B, Hennus M P, Wildenbeest J G, Mokry M, Bont L J, van der Vlist M, Calis J J A
Abstract excerpt
BACKGROUND: Respiratory syncytial virus (RSV) infection is the primary cause of lower respiratory tract infections in children <5 years of age. Monocytes, especially in the respiratory tract, are suggested to contribute to RSV pathology, but their role is incompletely understood. With transcriptomic profiling of blood and airway monocytes, we describe the role of monocytes in severe RSV infection. METHODS:...
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