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Single cell transcriptomics identifies distinct profiles in pediatric acute respiratory distress syndrome

30 Jun 2023

Abstract excerpt

Acute respiratory distress syndrome (ARDS), termed pediatric ARDS (pARDS) in children, is a severe form of acute respiratory failure (ARF). Pathologic immune responses are implicated in pARDS pathogenesis. Here, we present a description of microbial sequencing and single cell gene expression in tracheal aspirates (TAs) obtained longitudinally from infants with ARF. We show reduced interferon stimulated gene (ISG)...

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PMID: 37391405
DOI: 10.1038/s41467-023-39593-0

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