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Article

Human retinoic acid-inducible gene I (RIG-I) deficiency associated with susceptibility to classic Kaposi sarcoma.

The Journal of allergy and clinical immunology - 1 Jul 2026

Roussel Lucie, Bernier Stéphane, Langelier Mélanie, Sun Yichun, Mak Benjamin, Li Yongbiao, Perez Anna, Wloski Alexi, Angers Isabelle, Vinh Lily-Rose, Beauchamp Annie, Boissel Sarah, Watters A Kevin, Rousseau Simon, Routy Jean-Pierre, Calderon Virginie, Arias Carolina, Vinh Donald C

Abstract excerpt

BACKGROUND: Kaposi sarcoma (KS), driven by the DNA virus KS-associated herpesvirus (KSHV), arises in the context of T-cell immunosuppression (eg, human immunodeficiency virus infection, transplantation) or sporadically in ostensibly immunocompetent older adults (endemic or classic KS). The mechanisms underlying KS development without exogenous immunosuppression remain unclear. Retinoic acid-inducible gene I...

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PMID: 41780571
DOI: 10.1016/j.jaci.2026.02.027

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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