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Article

Exploration of the Tumour Biological Significance of PCLO in Gastric Cancer: Results from a Large Central European Cohort.

Pathobiology : journal of immunopathology, molecular and cellular biology - 1 Jan 2024

Bernhardt Maximilian, Behrens Hans-Michael, Krüger Sandra, Röcken Christoph

Abstract excerpt

INTRODUCTION: A recent multiregional whole-exome sequencing of 48 tumour samples from 9 gastric adenocarcinomas discovered PCLO mutations in 23 (47.9%) tumour samples. Based on that unexpected high prevalence of PCLO mutations, we hypothesized a tumour biological significance of PCLO in gastric cancer (GC). METHODS: Tumour samples (whole tissue sections) obtained from 466 patients resected for therapy-naive GC...

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Identifiers

PMID: 37935138
DOI: 10.1159/000534889
PMCID: PMC11126201

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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