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Deciphering the molecular and cellular atlas of immune cells in septic patients with different bacterial infections

2 Nov 2023

Abstract excerpt

BACKGROUND: Sepsis is a life-threatening organ dysfunction caused by abnormal immune responses to various, predominantly bacterial, infections. Different bacterial infections lead to substantial variation in disease manifestation and therapeutic strategies. However, the underlying cellular heterogeneity and mechanisms involved remain poorly understood. METHODS: Multiple bulk transcriptome datasets from septic...

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PMID: 37919720
DOI: 10.1186/s12967-023-04631-4

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