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Article

Extreme thrombocytosis with an aggressive evolution harboring a novel variant of calreticulin (CALR) in exon 3.

European journal of haematology - 1 Mar 2024

Bonnet Sarah, Carillo Serge, Legrand Baptiste, Burroni Barbara, Lavabre-Bertrand Thierry, Requirand Guilhem, Robert Nicolas, Fornero Lea, Al Mansoori Ahmed, Moreaux Jérôme, Cartron Guillaume, Gabellier Ludovic, Herbaux Charles

Abstract excerpt

We describe the case of a patient with extreme thrombocytosis whose evolution was rapidly fatal. No cause of secondary thrombocytosis was found. There was no sign of myelofibrosis but the megakaryocytes were small and dysplastic. The patient presented a calreticulin (CALR) variant in exon 3 (C105S), as well as concomitant mutations of ASXL1, U2AF1, and EZH2. This variant of CALR has never been described before,...

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PMID: 37918825
DOI: 10.1111/ejh.14126

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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