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Article

CALR type 1 mutations are associated with an increased incidence of myelofibrosis in young male patients.

Irish journal of medical science - 1 Apr 2023

Weir Philip, Hindley Andrew, Catherwood Mark, McMullin Mary Frances

Abstract excerpt

BACKGROUND: Calreticulin (CALR) mutations are commonly identified in patients with essential thrombocythaemia or myelofibrosis. CALR type 1 mutations are known to have a higher overall incidence in males but little is known about the risks of mutation subtypes on myelofibrotic change across patient age and sex. AIMS: To identify differences in the incidence of myelofibrotic change within subgroups of patients...

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Identifiers

PMID: 35672563
DOI: 10.1007/s11845-022-03047-1
PMCID: PMC10066159

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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CALR type 1 mutations are associated with an increased incidence of myelofibrosis in young male patients.PMID 35672563Read ↗

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Frequency of Calreticulin (CALR) Mutation and Its Clinical Prognostic Significance in Essential Thrombocythemia and Primary Myelofibrosis: A Meta-analysis.Semantic proximity Read ↗

The prognostic advantage of calreticulin mutations in myelofibrosis might be confined to type 1 or type 1-like CALR variantsSemantic proximity Read ↗

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