Article
In-depth immune profiling reveals advanced B- and T-cell differentiation to be associated with Th1-driven immune dysregulation in common variable immunodeficiency.
Clinical immunology (Orlando, Fla.) - 1 Dec 2023
Hultberg Jonas, Blixt Emelie, Göransson Robin, Adolfsson Jörgen, Govender Melissa, Larsson Marie, Nilsdotter-Augustinsson Åsa, Ernerudh Jan, Nyström Sofia
Abstract excerpt
Common variable immunodeficiency (CVID) is an inborn error of immunity characterized by low levels of antibodies. In addition to infections, many patients also suffer from T-helper 1-driven immune dysregulation, which is associated with increased mortality. The aim of this study was to perform in-depth characterization of the T and the B cell compartments in a well-defined cohort of patients affected by CVID and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.