Article
Familial patterns of immune dysregulation in CVID: insights from B- and T-cell phenotyping and antibody profiling.
Frontiers in immunology - 1 Jan 2026
Comans Suzanne E T, Sprenkeler Evelien G G, Koenen Mischa H, Simonetti Elles, Van Cranenbroek Bram, Van Rijssen Esther, Strik-Albers Riet, Koenen Hans J P M, van Dongen Jacques J M, Verhagen Lilly M, de Jonge Marien I, Henriet Stefanie S V
Abstract excerpt
Introduction: Common Variable Immunodeficiency (CVID) is a heterogeneous immune disorder characterized by a broad range of clinical manifestations. Its etiology is not yet fully understood. To gain insights into the immunological background of CVID in patients without a clearly defined genetic cause, we employed a genealogical research approach that included family members. This strategy aims to provide a more...
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