Article
Common Variable Immunodeficiency patients with a phenotypic profile of immunosenescence present with thrombocytopenia.
Scientific reports - 5 Jan 2017
Stuchlý Jan, Kanderová Veronika, Vlková Marcela, Heřmanová Ivana, Slámová Lucie, Pelák Ondřej, Taraldsrud Eli, Jílek Dalibor, Králíc Ková Pavlína, Fevang Børre, Trková Marie, Hrušák Ondřej, Froňková Eva, Šedivá Anna, Litzman Jiří, Kalina Tomáš
Abstract excerpt
Common variable immunodeficiency (CVID) is a heterogeneous group of diseases. Our aim was to define sub-groups of CVID patients with similar phenotypes and clinical characteristics. Using eight-color flow cytometry, we analyzed both B- and T-cell phenotypes in a cohort of 88 CVID patients and 48 healthy donors. A hierarchical clustering of probability binning "bins" yielded a separate cluster of 22 CVID patients...
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