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[Chronic neutrophilic leukemia/chronic eosinophilic leukemia].

[Rinsho ketsueki] The Japanese journal of clinical hematology - 1 Jan 2023

Kawashima Ichiro, Kirito Keita

Abstract excerpt

Chronic neutrophilic leukemia (CNL) is a clonal disorder that is characterized by increasing mature neutrophils. Colony stimulating factor 3 receptor (CSF3R) T618I mutation was frequently identified in patients with CNL and is defined as a molecular marker of the disease. Ruxolitinib, a JAK2 inhibitor, provided a promising therapeutic effect in a phase II study. In particular, ruxolitinib was more efficient for...

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PMID: 37914248
DOI: 10.11406/rinketsu.64.1326

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