Article
[The clinical characteristics, gene mutations and prognosis of chronic neutrophilic leukemia].
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi - 14 Jan 2017
Cui Y J, Jiang Q, Liu J Q, Li B, Xu Z F, Qin T J, Zhang Y, Cai W Y, Zhang H L, Fang L W, Pan L J, Hu N B, Qu S Q, Xiao Z J
Abstract excerpt
Objective: To investigate the clinical manifestation, cytogenetics, gene mutations and prognostic factors of chronic neutrophilic leukemia (CNL) . Methods: 16 CNL cases, according to WHO (2016) -definition, were reviewed retrospectively. Identifications of the CSF3R, ASXL1, SETBP1, CALR and MPL mutations were performed by direct sequencing. JAK2 V617F mutation was detected by AS-PCR. Results: Of the 16 CNL...
Topics
- Adult
- Aged
- Aged, 80 and over
- Bone Marrow
- Carrier Proteins
- Female
- Humans
- Janus Kinase 2
- Leukemia, Neutrophilic, Chronic
- Male
- Middle Aged
- Mutation
- Nuclear Proteins
- Polymerase Chain Reaction