Article
Tumor Volume Growth Rates and Doubling Times during Active Surveillance of IDH-mutant Low-Grade Glioma.
Clinical cancer research : an official journal of the American Association for Cancer Research - 5 Jan 2024
Bhatia Ankush, Moreno Raquel, Reiner Anne S, Nandakumar Subhiksha, Walch Henry S, Thomas Teena M, Nicklin Philip J, Choi Ye, Skakodub Anna, Malani Rachna, Prabhakaran Vivek, Tiwari Pallavi, Diaz Maria, Panageas Katherine S, Mellinghoff Ingo K, Bale Tejus A, Young Robert J
Abstract excerpt
PURPOSE: Isocitrate dehydrogenase-mutant (IDH-mt) gliomas are incurable primary brain tumors characterized by a slow-growing phase over several years followed by a rapid-growing malignant phase. We hypothesized that tumor volume growth rate (TVGR) on MRI may act as an earlier measure of clinical benefit during the active surveillance period. EXPERIMENTAL DESIGN: We integrated three-dimensional volumetric...
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