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Multidimensional fragmentomic profiling of cell-free DNA released from patient-derived organoids

28 Oct 2023

Abstract excerpt

BACKGROUND: Fragmentomics, the investigation of fragmentation patterns of cell-free DNA (cfDNA), has emerged as a promising strategy for the early detection of multiple cancers in the field of liquid biopsy. However, the clinical application of this approach has been hindered by a limited understanding of cfDNA biology. Furthermore, the prevalence of hematopoietic cell-derived cfDNA in plasma complicates the in...

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PMID: 37898819
DOI: 10.1186/s40246-023-00533-0

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