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Article

SIRT5 rs12216101 T>G variant is associated with liver damage and mitochondrial dysfunction in patients with non-alcoholic fatty liver disease.

Journal of hepatology - 1 Jan 2024

Salomone Federico, Pipitone Rosaria Maria, Longo Miriam, Malvestiti Francesco, Amorini Angela Maria, Distefano Alfio, Casirati Elia, Ciociola Ester, Iraci Nunzio, Leggio Loredana, Zito Rossella, Vicario Nunzio, Saoca Concetta, Pennisi Grazia, Cabibi Daniela, Lazzarino Giuseppe, Fracanzani Anna Ludovica, Dongiovanni Paola, Valenti Luca, Petta Salvatore, Volti Giovanni Li, Grimaudo Stefania

Abstract excerpt

BACKGROUND & AIMS: Sirtuin 5, encoded by the SIRT5 gene, is a NAD+-dependent deacylase that modulates mitochondrial metabolic processes through post-translational modifications. In this study, we aimed to examine the impact of the SIRT5 rs12216101 T>G non-coding single nucleotide polymorphism on disease severity in patients with non-alcoholic fatty liver disease (NAFLD). METHODS: The rs12216101 variant was...

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Share to Adenosine Triphosphate
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Share to Polymorphism, Single Nucleotide
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Identifiers

PMID: 37890719
DOI: 10.1016/j.jhep.2023.09.020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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